MedSynthea + Flatiron for Hematology Billing
Connect MedSynthea to Flatiron Health via SMART on FHIR to automate Hematology revenue cycle workflows end-to-end — from eligibility verification through CPT 85000-85999 coding and ERA payment posting, with 0% PHI in system logs.
Deploy Hematology Automation with Flatiron Health in 4 Steps
SMART on FHIR integration — no EHR vendor changes required.
Authenticate Flatiron Health
Authorize MedSynthea via SMART on FHIR. No vendor changes required — standard OAuth2/SMART credentials used.
Map Hematology Workflows
Configure CPT 85000-85999 (CBC/Coag) + 96400s fee schedules, payer contracts, and blood product billing prevention rules.
Activate AI Agents
9 agents begin processing Hematology encounters from Flatiron Health: eligibility, coding, scrubbing, and claim submission.
ERA Write-Back
Approved payment data posts back to Flatiron Health via SMART on FHIR write-back, closing the billing loop automatically.
Hematology Revenue Cycle Challenges MedSynthea Solves in Flatiron Health
Hematology billing is governed by CPT 85000-85999 (CBC/Coag) + 96400s coding complexity and strict payer LCD policies.
Blood product billing
Flatiron Health practices in Hematology face repeated denials for blood product billing. MedSynthea reads clinical notes from Flatiron via SMART on FHIR and flags documentation gaps before claim submission.
CPT 85000-85999 (CBC/Coag) + 96400s
MedSynthea's CODE agent validates all CPT 85000-85999 (CBC/Coag) + 96400s codes pulled from Flatiron Health clinical documentation against NCCI edit tables and payer-specific modifier rules.
Hematology/oncology infusion centers face 17% claim denial rates for blood product administration, where transfusion (CPT 36430) documentation must link blood product type, volume, and clinical indication to avoid automatic denial (ASH 2024).
9 AI Agents Working Inside Flatiron Health for Hematology
Each agent reads from and writes back to Flatiron Health via SMART on FHIR for a closed-loop Hematology billing workflow.
Scheduling Agent
Analyzes appointment patterns, flags high-risk no-show appointments, captures scheduling context (procedure type, referral source, insurance class) that affects downstream coding and billing decisions
In Flatiron: reads CPT 85000-85999 data via SMART on FHIR
Eligibility Agent
Queries 900+ payer databases in real time, validates active coverage, extracts benefit-level details (co-pay, deductible, out-of-pocket), identifies coverage gaps and prior auth requirements before the encounter begins
In Flatiron: reads CPT 85000-85999 data via SMART on FHIR
Documentation Agent
Converts encounter audio into structured clinical text using specialty-aware transcription models. Links every transcribed segment to the specific audio timestamp it came from, creating an immutable evidence chain. Formats output for the NOTE agent to structure into reviewable clinical documentation
In Flatiron: reads CPT 85000-85999 data via SMART on FHIR
Coding Agent
Reads structured clinical documentation, applies specialty-specific ICD-10 hierarchies and CPT code families, validates against payer-specific LCD policies and NCCI edit tables, applies correct modifiers, and proposes a complete reviewable code set linked to the clinical evidence that supports each code
In Flatiron: reads CPT 85000-85999 data via SMART on FHIR
Scrubber Agent
Scores every claim against 200+ denial variables before submission. Identifies modifier conflicts, missing prior authorizations, LCD coverage gaps, eligibility issues, and payer-specific policy violations. Routes high-risk claims for human review before they reach the payer, preventing denials at the source
In Flatiron: reads CPT 85000-85999 data via SMART on FHIR
Prior Auth Agent
Identifies prior authorization requirements from eligibility data and payer rules, assembles supporting clinical documentation, submits PA requests via payer APIs or electronic portals, tracks approval status in real time, and routes approvals back to the clinical workflow and Billing agent
In Flatiron: reads CPT 85000-85999 data via SMART on FHIR
Billing Agent
Submits validated claims to payer clearing houses or direct payer APIs, monitors submission acknowledgement in real time, tracks claim status through the payer adjudication process, flags abnormal hold times for follow-up, and passes accepted claims to the FLW agent for ongoing tracking
In Flatiron: reads CPT 85000-85999 data via SMART on FHIR
Denial Agent
Receives denial notifications, categorizes each denial by type (clinical necessity, coding, eligibility, authorization), retrieves original claim and clinical documentation, identifies the specific correction needed, assembles an appeal package with targeted documentation, and submits the appeal via payer portal or mail within the payer's filing window
In Flatiron: reads CPT 85000-85999 data via SMART on FHIR
Reconciliation Agent
Receives 835 EDI ERA files and EOB documents from payers, matches each payment line to the original claim, posts payments to the appropriate account, flags underpayments against contracted rates, identifies incorrect adjustment codes, calculates patient balance responsibilities, and generates reconciliation reports for financial review
In Flatiron: reads CPT 85000-85999 data via SMART on FHIR
Other Specialties Supported in Flatiron Health
MedSynthea automates all major specialties within Flatiron Health via SMART on FHIR.
Hematology Billing in Other EHR Systems
Flatiron Health + Hematology Integration — Frequently Asked Questions
How does MedSynthea integrate with Flatiron Health for Hematology billing?
MedSynthea connects to Flatiron Health via SMART on FHIR, reading clinical encounter data and writing approved CPT 85000-85999 (CBC/Coag) + 96400s codes and documentation back into the EHR automatically — without any custom software engineering.
Does MedSynthea support Flatiron Health for Hematology prior authorization?
Yes. MedSynthea's PA agent reads Hematology encounter data from Flatiron Health via SMART on FHIR, assembles required clinical documentation, and submits prior authorization requests automatically for Hematology procedures.
What Hematology CPT codes does MedSynthea validate in Flatiron Health?
MedSynthea's CODE agent validates CPT 85000-85999 (CBC/Coag) + 96400s against payer LCD policies and NCCI edit tables, then writes approved codes directly into Flatiron Health with full evidence traceability — every code linked to source clinical notes.
How long does Flatiron Health + MedSynthea setup take for a Hematology practice?
Most Hematology practices complete Flatiron Health integration in under 2 weeks. MedSynthea authenticates via SMART on FHIR — no EHR vendor code changes required. Configuration covers fee schedules, payer contracts, and Hematology-specific denial rules.
Connect Flatiron Health to MedSynthea for Hematology Billing
Zero custom engineering. SMART on FHIR authentication. Live Hematology automation in under 2 weeks.
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